• Unlike CRM exportins Cse and Xpot lack a C extension

  2019-08-05

  

  Unlike CRM1, exportins Cse1 and Xpot lack a C-extension and instead rely primarily on changes in HEAT-repeat conformation and direct Ran-cargo contacts to ensure low cargo-binding affinity in the cytosol and cooperative assembly of the exportin/Ran/cargo complex in the nucleus (Cook et al., 2005, Co

• br Clinical trials of CRM inhibitors KPT clinical trials hav

  2019-08-05

  

  Clinical trials of CRM1 inhibitors KPT-330 clinical trials have been initiated with promising very early results. One trial includes patients with advanced solid tumors whose disease has progressed after at least one prior therapy for metastatic disease (NCT01607905). Another trial includes patie

• br Diseases which have been

  2019-08-05

  

  Diseases which have been treated with proteins linked to HSA A number of therapeutic products conjugated to HSA have now been approved for clinical use (Table 2). For example, fatty YAP-TEAD Inhibitor 1 derivatives of human insulin bound to HSA have applications in the treatment of diabetes while

• br These component origins have been chosen as they are

  2019-08-05

  

  These component origins have been chosen as they GDC-0349 calculator are well-defined options related to developing with components (see for example Morisio and Torchiano (2002); Carney and Long (2000) and Gacek and Arief (2004)). The individual component origins (COTS, OSS, in-house developed co

• The classification of CK substrates based on

  2019-08-05

  

  The classification of CK2 substrates based on active enzyme subunit composition provides a framework for understanding the regulatory function of CK2β subunit. However, few experiments exist that functionally explore such classification [17], [18], [19], [20], [21], [22], [23]; this reflects practic

• br Conflict of interest br Acknowledgements This study

  2019-08-05

  

  Conflict of interest Acknowledgements This study was supported by the National Natural Science Foundation of China (No.31571839), the Chinese Ministry Program for New Century Excellent Talents in University (NCET-12-0865), and Special Fund for Agro-scientific Research in the Public Interest (N

• br Materials and methods br Results br Discussion

  2019-08-02

  

  Materials and methods Results Discussion Prolyl 4-hydroxylases are oxygenases with key roles in a variety of biological processes including oxygen sensing, siRNA regulation and collagen folding (Gorres and Raines, 2010). Hydroxyproline is particularly abundant in collagenous proteins which

• The instructive precedent for galectin phosphorylation is hu

  2019-08-02

  

  The instructive precedent for galectin phosphorylation is human galectin-3 (hGal-3). Its serine modification by protein kinase CK1 in the N-terminal tail is relevant for nuclear export during the course of apoptosis regulation and contact formation with the neural cell adhesion molecule L1 , , , . T

• River sand was graded in accordance with ASTM C see

  2019-08-02

  

  River sand was graded in accordance with ASTM C778 [47] (see Table 2). The graded sand had a water CFDA-SE of 1.00%, fineness modulus of 3.49 and specific gravity of 2350kg/m3. A polycarboxylate based superplasticizer called ZP with pH of 7±1 and specific gravity of 1.1±0.02 was also used to adjus

• br Cytochrome P monooxygenases Cytochrome

  2019-08-02

  

  Cytochrome P450 monooxygenases Cytochrome P450 monooxygenases (P450s) belong to one of Nature’s most versatile group of enzymes for C–H functionalization and are able to perform challenging regioselective and stereoselective activations of remote, unactivated C(sp3)–H bonds, for which there are o

• It is without doubt that the vagina plays a significant

  2019-08-02

  

  It is without doubt that the vagina plays a significant role in the perception of coital stimulation leading to sexual arousal and, finally, orgasm. In response to sensory stimulation, relaxation of vaginal vascular and nonvascular smooth muscle occurs, resulting in an increase in local blood flow a

• It is also critical that

  2019-08-02

  

  It is also critical that APC/CCDC20 is inhibited by MCC during the spindle assembly checkpoint, prior to correct chromosome alignment on the mitotic spindle (Box 1, reviewed in 13, 34). As proposed in [13] and demonstrated in [82], human MCC is a heterotetrameric complex consisting of its own molecu

• Introduction DHFR is an important enzyme in both mammals

  2019-08-02

  

  Introduction DHFR is an important enzyme in both mammals and microorganism including Mycobacterium tuberculosis (Mtb). It catalyzes folic Natural Product Library is conversion to dihydro and tetrahydro folic acid which is a crucial step in folate pathway [1]. Inhibition of folate pathway leads to i

• Introduction The term myeloproliferative disorders was first

  2019-08-02

  

  Introduction The term “myeloproliferative disorders” was first proposed by William Dameshek in 1951. With the discovery of the Philadelphia chromosome, myeloproliferative disorders were classified into two groups: BCR-ABL positive chronic myeloid leukemia (CML) and BCR-ABL negative chronic myelopro

• At ngL DEX did not affect our

  2019-08-02

  

  At 3000ngL−1, DEX did not affect our investigated parameters, suggesting that DEX is regulated by CYP450 in a biphasic way, a response to xenobiotics that is not uncommon (Heinrichs et al., 1994). These data might also suggest that fish adapted to DEX exposure. It was previously shown that, dependin

15345 records 1010/1023 page Previous Next First page 上5页 10061007100810091010 下5页 Last page