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Cy7 NHS ester (non-sulfonated) mg br Conflict of interest st
2024-12-19
Conflict of interest statement Benign prostatic hyperplasia (BPH) is a highly complex process characterized by an increased number of epithelial and stromal Cy7 NHS ester (non-sulfonated) mg in the transition zone. , , Autopsy studies by McNeal detail the evolution of histological changes withi
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br Research perspective In vitro and
2024-12-19
Research perspective In vitro and in vivo studies have demonstrated that increased LPA/ATX signaling contributes to cancer initiation and progression. Recent findings on the role of non-tumoral ATX in cancer progression and metastasis highlighted a new functional contribution for the microenviron
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Introduction Lysophosphatidic acid LPA is
2024-12-19
Introduction Lysophosphatidic 3-Deazaneplanocin A (LPA) is a key, serum-borne phospholipid, regulating a number of cellular processes such as proliferation, migration and differentiation through its interaction with G-protein coupled receptors. LPA receptor signaling has been implicated in several
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Several approved and or experimental
2024-12-19
Several approved and/or experimental drugs, together with natural compounds, have been reported to induce autophagy in different cancer types [70], [71], [72] (Table 1). In the next paragraphs, we will review more in detail a group of these agents selected in relation to their promising future outco
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The take home message here is
2024-12-19
The take-home message here is that, although Aurora A phosphorylated on T288 is the activated isoform of Aurora A, measuring the level of phosphorylation of T288 does not reflect Aurora A kinase activity (Figure 5). What would be the most appropriate readout for an in vivo Aurora A kinase activity
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br Experimental section br Acknowledgements br Introduction
2024-12-19
Experimental section Acknowledgements Introduction DJ-1 is a highly conserved, homodimeric protein that was originally cloned as an oncogene capable of transforming Kinase Inhibitor Library synthesis in cooperation with activated ras[1]. DJ-1 is over-expressed in multiple tumor types and i
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br Material and methods br Results br
2024-12-19
Material and methods Results Discussion The present study demonstrates for the first time that Mino selectively induces apoptosis in Jurkat CX5461 via an H2O2 signaling-dependent mechanism. Structurally, Mino is composed of a C10 and C12 phenol group, C12a hydroxyl group, and C1 and C11 al
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br Conflicts of interest br Introduction Photodynamic Therap
2024-12-19
Conflicts of interest Introduction Photodynamic Therapy (PDT) is a technique used for the treatment of several malignant and non malignant diseases (Akimoto, 2016, Keyal, Bhatta, Wang, 2016, Morton, Szeimies, Sidoroff, Wennberg, Basset-Seguin, Calzavara-Pinton, Gilaberte, Hofbauer, Hunger, Kar
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In order to further explore
2024-12-19
In order to further explore whether the cytoprotective effect of isogarcinol against oxidative stress in H2O2-induced HepG2 rosavin is a consequence of the breakdown of the endogenous antioxidant defence mechanism, we measured the LDH release, MDA levels, GSH levels and SOD activity. A large body o
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The habit of prescribing antibiotics
2024-12-19
The habit of prescribing Eplerenone “just-in-case” there is an infection is based on the misguided perception that antibiotics are “safe” drugs and therefore pose little risk to patients. Surgeons need to dispel this myth. In the outpatient setting, antibiotic-associated ADEs account for 19% of all
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br Eprosartan The AT R
2024-12-19
Eprosartan The AT1R antagonist eprosartan is approved for the treatment of essential D-(-)-Salicin and may be administered using a convenient once-daily regimen. The drug is a well-tolerated and effective antihypertensive agent with benefit in the secondary prevention of cerebrovascular events,
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In our study we provide evidence for the
2024-12-19
In our study we provide evidence for the existence of an endosome-lysosomal pathway for the proteolytic degradation of AR triggered by its interaction with the ESCRT-I component TSG101. The following findings of this study support this notion: (1) We showed that TS101 interacts with endogenous or ec
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br Conclusions br Material and methods br
2024-12-19
Conclusions Material and methods Conflicts of interest Acknowledgements Introduction Currently more than 30 human proteins are implicated in a range of degenerative disorders owing to their misfolding and misassembly into various aggregate structures and leading to at least 20 serious
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How do increased levels of ammonia as observed in
2024-12-19
How do increased levels of ammonia as observed in clinical HE constrain synaptic plasticity? Numerous studies have investigated the modulation of signal transduction pathways activated in LTP or LTD irrespective of being necessary or sufficient for changes in synaptic efficacy (Wen et al., 2013). Ye
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Fmoc-Cl Our previous study revealed expression of AhR in
2024-12-18
Our previous study revealed expression of AhR in human parotid gland in cytoplasm of striated duct Fmoc-Cl (Drozdzik, Kowalczyk, Urasińska, & Kurzawski, 2013). In a further study we observed regulation of AhR expression and function by its specific inducer, i.e. 2,3,7,8-tetrachlorodibenzo-p-dioxin (