• Lyso-Tracker Red for Nanoparticle Trafficking

  2026-08-14

  Discover how Lyso-Tracker Red supports lysosome labeling in live cells and helps distinguish nanoparticle uptake, acidic compartment routing, and lysosomal escape. This article translates findings from a laminarin vaccine-nanoparticle study into practical assay decisions.

• TRPM3 Regulation by Neurosteroids and Primidone

  2026-08-14

  The reference study defines how pregnenolone sulfate, CIM 0216, and primidone interact with the TRPM3 channel by combining cryo-EM structures with electrophysiology, molecular dynamics, and biochemical analyses. Its findings connect ligand recognition to TRPM3 gating and provide a structural framework for interpreting gain-of-function disease mutations and developing TRPM3-directed therapies.

• ATRX Loss Sensitizes Glioma Cells to RTK Inhibitors

  2026-08-13

  The reference study identifies ATRX deficiency as a potential biomarker of increased sensitivity to multi-targeted receptor tyrosine kinase and PDGFR inhibitors in high-grade glioma cells. It also reports enhanced toxicity when these inhibitors are combined with Temozolomide, supporting further investigation of ATRX status in glioma treatment-response studies.

• SW033291: A 15-PGDH Inhibitor Workflow

  2026-08-13

  SW033291 provides a precise way to connect 15-PGDH inhibition with prostaglandin E2 elevation, hematopoietic stem cell expansion, and tissue regeneration research. This workflow translates recent muscle-repair findings into practical enzyme, cell, and translational assay designs while emphasizing controls and troubleshooting.

• Tacrine Hydrochloride Hydrate: Assay Logic

  2026-08-12

  Tacrine hydrochloride hydrate, also known as Tetrahydroaminacrine, is examined here as a reference compound for mechanism-resolved Alzheimer’s disease research. This article focuses on exposure control, assay interpretation, and metabolism-aware experimental design rather than repeating a conventional drug-development overview.

• Targeted NAC Nanoparticles Suppress OA Ferroptosis

  2026-08-12

  The reference study develops chondroitin sulfate-modified PLGA nanoparticles that prolong intra-articular NAC exposure and target chondrocytes in osteoarthritis. Its results connect glutathione maintenance and GPX4-dependent ferroptosis inhibition with reduced cartilage damage, providing a mechanistic framework for localized redox therapy.

• Talabostat mesylate: DPP4/FAP Research Workflows

  2026-08-11

  Talabostat mesylate, also called PT-100 or Val-boroPro, supports parallel investigation of DPP4/FAP biology, tumor microenvironment modulation, and CARD8-dependent pyroptosis. This workflow-oriented guide shows how to separate protease inhibition from T-cell fate effects, improve solution handling, and build interpretable cancer and immunology assays.

• Fibroblast Signals and Lapatinib Resistance in ESCC

  2026-08-11

  Saito et al. show that esophageal fibroblast-derived signals can stimulate ESCC growth and functionally reduce lapatinib sensitivity through heterogeneous HGF/MET and FGF/FGFR dependencies. The study’s conditioned-medium and inhibitor-based design provides a useful framework for investigating stromal contributions to treatment resistance in cancer research.

• H5N1 mRNA Vaccine Protection in Dairy Cows

  2026-08-10

  A hemagglutinin-based mRNA–lipid nanoparticle vaccine protected lactating dairy cows from high-dose H5N1 challenge and maintained substantial protection 19 weeks after the first immunization. The study provides an important in vivo demonstration that an mRNA vaccine platform can be evaluated in high-yielding cattle without apparent effects on health or milk production, while also clarifying the evidence and translational gaps that remain.

• Mitochondrial Transfer in Orofacial Inflammatory Pain

  2026-08-09

  Li et al. show that satellite glial cells transfer functional mitochondria to trigeminal ganglion neurons during acute inflammation through tunneling nanotubes and extracellular uptake. The transferred organelles restore mitophagy, strengthen mitochondria–endoplasmic reticulum contact sites, normalize calcium homeostasis, and reduce neuronal hyperexcitability through an ATL1-dependent mechanism.

• GST-Mediated Lambda-Cyhalothrin Resistance in M. usitatus

  2026-08-08

  Dong and colleagues show that glutathione S-transferase, particularly MuGSTs1, strengthens the antioxidant defense of Megalurothrips usitatus during lambda-cyhalothrin exposure. Pharmacological GST inhibition with diethyl maleate reduced antioxidant capacity and sharply increased insecticide sensitivity, providing a mechanistic framework for resistance research.

• TQB3720 Activates Ferroptosis Through AR/GPX4

  2026-08-07

  The reference study identifies an AR/SP1/GPX4 regulatory route through which the second-generation androgen receptor antagonist TQB3720 suppresses prostate cancer growth and promotes ferroptosis. Its combination of cellular, organoid, xenograft, redox, lipid-peroxidation, and transcriptional assays provides a useful framework for linking AR signaling disruption with iron-dependent oxidative cell death.

• ER Stress Impairs Intestinal Stem Cells via GRP78/ATF6/CHOP

  2026-08-07

  This study demonstrates that tunicamycin-induced endoplasmic reticulum (ER) stress significantly impairs intestinal stem cell number and differentiation in mice, mediated by activation of the GRP78/ATF6/CHOP signaling pathway and suppression of the p44/42 MAPK pathway. These findings clarify the molecular link between ER stress and intestinal barrier dysfunction, offering a mechanistic foundation for future research on targeted interventions in gastrointestinal disease.

• Leptin (116-130), amide, mouse: Optimizing Metabolic Researc

  2026-08-06

  Leptin (116-130), amide, mouse empowers researchers to dissect energy homeostasis, obesity, and diabetes mechanisms with precision. This article delivers actionable workflows, troubleshooting guidance, and fresh insights for leveraging this soluble leptin fragment in advanced experimental designs.

• Amikacin Sulfate Applications: Intracellular Delivery & Prot

  2026-08-06

  Amikacin Sulfate empowers researchers with robust, dose-optimized workflows for intracellular targeting of non-tuberculous mycobacterial infections. Explore advanced experimental setups, troubleshooting strategies, and the latest insights on maximizing bactericidal efficacy while minimizing toxicity.

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