• Axl has been reported to

  2023-11-02

  

  Axl has been reported to mediate cell-cell adhesion and sphere-growth [11], [18] and to be important for metastasis to secondary organs [12], [14], [20]. We found an Axl-dependent CCRCC-ability of sphere-formation and repopulation after non-adhesive growth. Axl-inhibited cells could not attach to ea

• Fencilli et al reported derivatives of PHA which demonstrate

  2023-11-02

  

  Fencilli et al. reported derivatives of PHA-680626 (15) which demonstrated strong anti-proliferative activity against large group of leukaemia cell lines including IM-resistant BAF3 cells expressing mutants like T315I, M351T and E255K. Decrease in Histone H3 phosphorylation led to induction of endo-

• The therapeutic potential of ML induced MET

  2023-11-02

  

  The therapeutic potential of ML327-induced MET against Celastrol of mesenchymal origin has not been explored. In the present study, we hypothesized that induction of MET using ML327 would block the growth of ES cells and sensitize to TRAIL-mediated apoptosis. Herein, we report that ML327 induces ap

• The levels of Mcl and FLIP are

  2023-11-02

  

  The levels of Mcl-1 and FLIP are homeostatically controlled by transcriptional and posttranslational processes. Accumulating evidence suggested that intracellular signaling molecules such as Akt are crucial to the transcription of Mcl-1 and FLIP [30], [31]. The constitutive activation of Akt is det

• br Results br Discussion Control

  2023-11-02

  

  Results Discussion Control of chronic inflammation is important in several inflammatory conditions like asthma, rheumatoid arthritis and fibrosis in lung diseases. The regulatory pathways that control chronic inflammation are complex and multi-factorial. Over expression of inflammatory mediato

• It is worth noting that

  2023-11-02

  

  It is worth noting that in S. cerevisiae, the control of two cell-cycle checkpoints requiring Mcm1 involves two very different mechanisms. At the G1/S transition, Mcm1 transactivation activity is inhibited by Yox1 and Yhp1 repressors, whose expression is periodically regulated through the cell cycle

• Introduction Cardiovascular disease is the principal cause o

  2023-11-02

  

  Introduction Cardiovascular disease is the principal cause of morbidity and mortality in patients with Ampicillin Trihydrate receptor (1). Comprehensive management of these patients includes not only adequate glycemic control but also attention to additional recognized risk factors. Hypertension i

• APP is a member of a

  2023-11-02

  

  APP is a member of a conserved protein family that also includes amyloid precursor-like proteins 1 and 2 (APLP1, APLP2).8, 9, 10 The proteins in this family are type I single-pass transmembrane Nevirapine australia with receptor-like structural features but not entirely clear cellular functions.11,

• Synaptic scaling up is induced within primary visual cortex

  2023-11-02

  

  Synaptic scaling up is induced within primary visual DGAT-1 inhibitor (V1) by brief sensory deprivation (Desai et al., 2002; Lambo and Turrigiano, 2013). Several studies have examined the transcriptional changes within extracts of V1 following visual deprivation protocols (Lachance and Chaudhuri, 2

• br Introduction Breast cancer is the

  2023-11-02

  

  Introduction Breast cancer is the most frequently occurring cancer in women, and despite the development of new therapies there has been little decline in the mortality rate over the past decade (Siegel et al., 2015). This is partly due to the genetic diversity of breast cancers, such that there

• ZM 306416 mg Various compounds have been designed to inhibit

  2023-11-01

  

  Various compounds have been designed to inhibit aldose reductase (AR) [12]. These compounds can be classified into two main categories, the first category comprises those containing a carboxylic ZM 306416 mg moiety, for example, 3-thiazolidineacetic acid derivative, which has been reported to be a p

• Kartogenin The mechanisms that control Ahr transcription are

  2023-11-01

  

  The mechanisms that control Ahr transcription are poorly understood, especially when considering cell type-specific regulation. A recent report suggested that the Ahr transcription might be directly promoted by RORγt [retinoic Kartogenin receptor (RAR)-related orphan receptor γt] based on ChIP-Seq

• Aberrant or a sustained activation

  2023-11-01

  

  Aberrant or a sustained activation of AhR signaling pathway, triggered by exogenous toxic ligands such as dioxins, PAHs or polychlorinated biphenyls (PCBs), is a well-described biological process engaged during tumor initiation and/or promotion in various tissues (e.g. liver, lung, skin)(reviewed in

• br Roles for GMF in Endocytic Traffic In addition to

  2023-11-01

  

  Roles for GMF in Endocytic Traffic In addition to its roles in cell migration, GMF regulates actin-dependent endocytosis in yeast and mammals 13, 14, 50, and promotes the turnover of focal adhesions in immune GDC-0349 42, 51. Vinculin, a central component of focal adhesions that anchors cells to

• br Acknowledgements br Introduction Autoantibodies directed

  2023-11-01

  

  Acknowledgements Introduction Autoantibodies directed at neurotransmitter receptors and ion channels are pathogenic and/or biomarkers in several autoimmune neurological diseases [1]. For example, autoantibodies directed against voltage-gated potassium channels, the P/Q-type (α1A) voltage-gated

14961 records 230/998 page Previous Next First page 上5页 226227228229230 下5页 Last page