• Constitutive activity of Ras Raf MEK

  2019-12-26

  

  Constitutive activity of Ras/Raf/MEK/ERK pathway plays a critical role on melanoma growth, thus inhibition of activity of Ras, Raf and MEK can reduce ERK activity, leading to a decrease in melanoma cell proliferation, survival and invasion (Burotto et al., 2014; Paluncic et al., 2016). Our results a

• Gupta et al have shown that a genetic

  2019-12-26

  

  Gupta et al have shown that a genetic variant associated with the 5 vascular diseases (coronary artery disease, migraine, carotid artery dissection, fibro-muscular dysplasia, and hypertension) is a distal regulator of the ET-1 gene [30]. They found that a single nucleotide polymorphism (SNP) located

• An analysis of EBI expression on dendritic cells DCs showed

  2019-12-26

  

  An analysis of EBI2 expression on dendritic cells (DCs) showed that EBI2 is highly expressed on CD4+ conventional cDCs. In line with this mice deficient for EBI2 largely lack this subset of cDCs in the spleen. Furthermore, the localization of the residual cells is disturbed [10,11]. It was found tha

• br Ubiquitin ligases Ubiquitin ligases are categorized

  2019-12-26

  

  Ubiquitin ligases Ubiquitin ligases are categorized into different SJ 172550 based on their specific structural configuration and the composition of subunits—HECT (homologous to E6-AP1 (E6-associated protein 1) carboxy-terminus)-type, RING (really interesting new gene)-finger-type, U-box-type, or

• The ubiquitin like modifier NEDD NEURAL PRECURSOR

  2019-12-26

  

  The ubiquitin-like modifier NEDD8 (NEURAL PRECURSOR CELL EXPRESSED, DEVELOPMENTALLY DOWN-REGULATED 8) uses similar enzymatic machineries for NEDD8 conjugation as ubiquitin (Figure 1) [11, 12, 13, 14]. In plants as well as in other eukaryotes, the number of E3 ligases for NEDD8 and the number of know

• The E enzyme is the apex for downstream

  2019-12-26

  

  The E1 enzyme is the apex for downstream enzymatic cascades and signaling pathways mediated by Ub and Ub-like proteins (Ubls) (Pickart, 2001). Studying characteristics of E1 and its catalytic functions may throw light to the role of ubiquitination in cell development. All known eukaryotic E1 are mon

• Introduction Protein ubiquitination is a posttranslational m

  2019-12-26

  

  Introduction Protein ubiquitination is a posttranslational modification that plays a major role in almost all cellular processes in eukaryotes (Hochstrasser, 2009; Komander & Rape, 2012). It involves the covalent attachment of ubiquitin (Ub) via its C-terminal glycine carboxylate to a primary amine

• Common enzyme quantitative methods include enzyme

  2019-12-26

  

  Common enzyme quantitative methods include enzyme-linked immunosorbent assay [,] (ELISA), chemiluminescence (CLIA) [, , ] and immunochromatography []. The advantages of ELISA are cost reduction and automation, but non-specific reaction caused by HOOK effect, false positive caused by cross-contaminat

• br DDR in atherosclerosis and vascular disease

  2019-12-26

  

  DDR1 in atherosclerosis and vascular disease The Canadian group of Bendeck, explored the role of DDR1 in repair following arterial injury in rats [30]. DDR1 protein levels, assessed via Western blots prepared from arterial extracts taken at various times after injury, showed DDR1 protein dramatic

• A topological property P is said to

  2019-12-24

  

  A topological property P is said to be cut point hereditary [3] if whenever a space X has property P, then, for every there exists some separation of such that each of and has property P. A space X is called connected ordered topological space (COTS) [5] if it is connected and has the property

• The COMT gene maps to chromosome q Grossman et

  2019-12-24

  

  The COMT gene maps to chromosome 22q11.2 (Grossman et al., 1992) and has two protein isoforms. The differences between S-COMT and longer MB-COMT are in the N-termini, which use alternative translation initiation sites and promoters. These two isoforms display different affinity and capacity for COMT

• As plants can only take up P in an

  2019-12-24

  

  As plants can only take up P in an inorganic orthophosphate form, it was expected that the proportion of orthophosphate P in the OA would be a good indication of the availability of the P in the OA. While the P speciation of the COMP sample could not be determined by deconvolution due to the broadne

• To avoid the difficulty of

  2019-12-24

  

  To avoid the difficulty of the nonsmooth constraints, a sequence of smooth problems by using smoothing functions have been progressively approximated this nonsmooth problem. To date, there have been many smoothing functions, such as perturbed Fischer–Burmeister (FB), Chen–Harker–Kanzow–Smale (CHKS),

• br Agonist binding ETA activation

  2019-12-24

  

  Agonist binding ETA activation is promoted by binding of the endogenous peptidergic agonists to their orthosteric binding site on the receptor. ET1 and ET2 (Trp6-Leu7-ET1) bind with equal high affinity to ETA, whereas the third endogenous isopeptide ET3 (Thr2-Phe4-Thr5-Tyr6-Lys7-Tyr14-ET1) binds

• Introduction Glucose is the major carbon source in

  2019-12-24

  

  Introduction Glucose is the major carbon source in most organisms. Cancer PRIMA-1 receptor in particular require a steady source of energy to maintain growth and proliferation, and preferentially use glycolysis for their energy supply even under aerobic conditions. Glucose uptake in mammals is mai

14918 records 901/995 page Previous Next First page 上5页 901902903904905 下5页 Last page